So much of what Joe Gregorio discussed in 2014 still applies. Check out his manifesto post too.

Play Stop Writing JavaScript Frameworks - Joe Gregorio - OSCON 2015

I still think JavaScript was one of the worst things to happen to the Internet, but I also realise I live in the Real World. Vanilla JS and web standards would be far preferable to the cornicopia of incompatible, resource expensive, and brittle frameworks around today.